COVID-19 Information: COVID-19 Information: View the latest information about COVID-19 from the City of St. Louis Department of Health View the latest information about COVID-19 from the City of St. Louis Department of Health St Louis is home to a variety of attractions, activities & events for all ages. Discover top STL restaurants, hotels in St Louis, St Louis entertainment, St Louis museums & more unique locations. Saint Louis is the perfect Midwest vacation destination for the entire family. Book your tickets online for the top things to do in Saint Louis, Missouri on Tripadvisor: See 75,961 traveler reviews and photos of Saint Louis tourist attractions. Find what to do today, this weekend, or in June. We have reviews of the best places to see in Saint Louis. Visit top-rated & must-see attractions. For other uses, see Saint Louis. St. Louis (/ seɪnt ˈluːɪs /) is an independent city in Missouri. It is the largest metropolitan area in the state of Missouri; however, the independent city of St. Louis is the second largest city in Missouri, behind Kansas City. Saint Louis, Missouri The history of St. Louis has been heavily influenced by Westward expansion and blues music. The big must-see in this region is the Gateway Arch, while other important sites include the Museum of Westward Expansion, the St. Louis Cathedral and the Anheuser-Busch factory tour. The city offers plenty for the whole family. St. Louis remains a major transportation and distribution centre. The city is the second largest inland port in the country and is a major part of the Inland Waterway System. It is the northernmost point on the Mississippi that remains ice-free all year; major cargoes include grain, coal, petroleum products, and chemicals.